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Pathology Quiz

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1 / 50

What is the preferred treatment of painful synovial chondromatosis of the hip in a young adult as seen in the radiograph in Figure?

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2 / 50

For which of the following patients would a bone marrow biopsy be indicated during tumor staging?

3 / 50

A 65-year-old patient without a history of cancer presents with thigh pain and a lytic lesion in the left femur. A CT scan of the chest, abdomen, and pelvis as well as a bone scan show this to be an isolated tumor. Biopsy confirms adenocarcinoma. What is the most likely primary source of this patient’s tumor?

4 / 50

A 21-year-old man presents with a destructive lesion in his distal femur. A chest radiograph reveals multiple lung nodules. Which of the following tumors has the highest rate of lung metastases?

5 / 50

Which of the following is true regarding apoptosis?

6 / 50

A 9-year-old child presents to your office after he felt a painful snap in his arm while throwing a baseball. He is otherwise in good health and has no family history of disease. A radiograph of his arm is shown in Figure . What is the next step in your management?

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7 / 50

A 59-year-old female presents with a metastatic spinal tumor and has a lytic lesion in the T12 vertebral body. The process of bone resorption in her lytic lesion is mediated by :

8 / 50

A 14-year-old boy is brought to the emergency department after falling onto his right shoulder. Radiographs are shown in Figure A. Which of the following is most likely to occur with curettage and bone grafting of this lesion?

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9 / 50

Which of the following conditions can be characterized by excessive bone resorption and disordered bone formation?

10 / 50

All of the following are true of multiple hereditary exostoses (MHE) EXCEPT?

11 / 50

A 75-year-old man presents with a displaced femoral neck fracture. During your surgical exposure for a hemiarthroplasty, the femoral neck has fractured through a pathologic lesion which is diagnosed as a lymphoma on frozen section. The lesion is located in the center of the femoral neck and the calcar femorale is not involved. Your treatment should include:

12 / 50

Giant cell tumors of bone can occur in many different areas throughout the body. All of the following are common locations for giant cell tumors of bone EXCEPT?

13 / 50

Intralesional curettage and bone grafting is an accepted component of the treatment plan for all of the following conditions EXCEPT?

14 / 50

Heterotopic ossification has been recognized as a rare complication from Steinmann pins placed in which location for traction purposes?

15 / 50

Which inherited condition shows a strong association with extra-abdominal desmoid tumors?

16 / 50

Endothelin 1 is known to be involved in which of the following disease processes?

17 / 50

Which of the following most accurately lists the most common location of osteosarcoma in decreasing frequency?

18 / 50

The fusion gene resulting from the chromosomal translocation t(X;18)(p11;q11) is chararcteristically found in which malignancy?

19 / 50

Intralesional surgical resection is considered standard of care for which of the following conditions?

20 / 50

Lytic bone lesions, commonly seen in metastatic bone disease or multiple myeloma, are due to which of the following mechanisms?

21 / 50

What is the preferred definitive treatment for biopsy proven grade 2 chondrosarcoma of the distal femur without evidence of metastases?

22 / 50

A 8-year-old boy presents with knee pain and an effusion. Biopsy and staging studies show a distal femoral osteosarcoma with contamination of the knee joint. Which of the following treatment options will provide this child with the best chance of local control and the highest level of function?

23 / 50

A 22-year-old female with hereditary osteochondromas has difficulty supinating and pronating her forearm. Radiographs are shown in Figure A. Which of the following procedures would most effectively improve forearm rotation in this patient?

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24 / 50

Which of the following correctly lists the life expectancy from least life expectancy to greatest life expectancy when a patient presents with metastatic carcinoma to bone?

25 / 50

What is the appropriate treatment for a 10-year-old boy with Ewing’s sarcoma isolated to the proximal femur?

26 / 50

A 23-year-old soccer player sustains an anterior cruciate ligament (ACL) tear and is scheduled for reconstruction. He has questions regarding the use of autografts. Which of the following statements is true regarding bone-patellar tendon-bone (BTB) autograft in comparison to quadrupled hamstring autograft for ACL reconstruction?

27 / 50

Patients with which of the following conditions have the highest risk of malignant transformation?

28 / 50

The chomosomal translocation t(X;18)is found in which of the following conditions?

29 / 50

Doxorubicin, a common chemotherapeutic agent used in the treatment of osteosarcoma, has which of the following major dose-limiting toxicities?

30 / 50

Which of the following tumors is chemotherapy and radiation therapy resistant?

31 / 50

A 24-year-old man has had pain in the right index finger for the past 9 months. The pain is completely relieved with ibuprofen. An AP radiograph and CT scan are shown in Figures A and B respectively. Which of the following is true regarding this lesion?

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32 / 50

Pharmacologically induced apoptosis occurs during the medical therapy of which of the following disorders?

33 / 50

A mutation in a G(s) alpha protein (activating G protein that increases cAMP) results in which of the following diseases?

34 / 50

All of the following statements regarding Paget’s sarcoma are correct EXCEPT?

35 / 50

What is the most appropriate treatment for a 65-year-old female with a 100-pack year tobacco history who presents with a new painful lytic lesion in her femoral diaphysis?

36 / 50

What is the most common cause for an aggressive lytic bone lesion in a patient above 40-years-old?

37 / 50

A surgeon resects a small, superficial, mobile lesion from the thigh. Pathological review of the specimen suggests it is a low-grade soft tissue sarcoma with positive surgical margins. After staging the patient, no other sites of disease are identified. What is the next most appropriate treatment for this patient?

38 / 50

All of the following are necessary steps in metastasis of a malignant cell EXCEPT?

39 / 50

All of the following are characteristic of McCune-Albright syndrome EXCEPT?

40 / 50

After tumor staging, what is the most appropriate treatment for a 17-year-old male with stage IIb Ewing’s sarcoma in his proximal tibia?

41 / 50

Which of the following diseases carries greater than 50% risk of developing a malignancy?

42 / 50

Giant cell tumors of bone can be locally aggressive and result in significant bone destruction. Which of the following is responsible for this type of bone destruction?

43 / 50

A 58-year-old man presents to your clinic with a 4-cm deep mass in his left thigh. It has been slowly expanding over the last 6 months. Radiographs show no evidence of bony involvement or soft tissue calcifications within the lesion. Which of the following is most appropriate at this time?

44 / 50

Which of the following is NOT associated with the condition shown in figure?

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45 / 50

An elderly female has just been diagnosed with lung cancer. If her cancer metastasizes to bone, what is the most common site of subsequent pathologic fracture?

46 / 50

Metastatic bony lesions that occur distal to the elbows or knees are most likely to originate from which one of the following primary organs?

47 / 50

A 59-year-old female with a history of biopsy proven metastatic renal cell carcinoma presents with a thoracic spine lesion consistent with renal cell carcinoma. She has lower extremity weakness and sustained clonus bilaterally. What is the most appropriate management prior to surgery?

48 / 50

Sixty Gy is a typical radiation dose for which of the following indications?

49 / 50

All of the following have been shown in the literature to increase the risk of heterotopic ossification EXCEPT?

50 / 50

Which of the following statements regarding rhabdomyosarcoma is true?

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