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Pathology Quiz

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1 / 50

Which treatment factor has shown to be most important for five-year disease-free survival in patients with subcutaneous sarcomas?

2 / 50

In patients with an extremity-based osteosarcoma without metastasis, all of the following are risk factors for disease progression and poor outcomes EXCEPT?

3 / 50

A defect of which of the following genes results in bony abnormalities, is associated with an increased risk of chondrosarcoma, and is inherited in an autosomal dominant manner?

4 / 50

An 8-year-old boy complains of left shoulder pain after a collision with his younger brother. He was asymptomatic prior to the incident. Which of the following treatments is most appropriate at this time?

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5 / 50

A mutation in a G(s) alpha protein (activating G protein that increases cAMP) results in which of the following diseases?

6 / 50

What is the major side-effect of doxorubicin?

7 / 50

A 39-year-old male is diagnosed with myxoid liposarcoma of the thigh. Radiation therapy is being considered in adjunct to surgical excision. Which of the following is true regarding radiation therapy in soft tissue sarcoma?

8 / 50

A 75-year-old man presents with a displaced femoral neck fracture. During your surgical exposure for a hemiarthroplasty, the femoral neck has fractured through a pathologic lesion which is diagnosed as a lymphoma on frozen section. The lesion is located in the center of the femoral neck and the calcar femorale is not involved. Your treatment should include:

9 / 50

Paget’s disease may predispose a patient to the development of which of the following malignant neoplasms?

10 / 50

Which of the following conditions can be characterized by excessive bone resorption and disordered bone formation?

11 / 50

Giant cell tumors of bone can occur in many different areas throughout the body. All of the following are common locations for giant cell tumors of bone EXCEPT?

12 / 50

Rates of recurrence for patients with chondrosarcoma are most directly related to which of the following?

13 / 50

After tumor staging, what is the most appropriate treatment for a 17-year-old male with stage IIb Ewing’s sarcoma in his proximal tibia?

14 / 50

All of the following statements regarding hereditary multiple exostosis (HME) are correct EXCEPT?

15 / 50

A 23-year-old soccer player sustains an anterior cruciate ligament (ACL) tear and is scheduled for reconstruction. He has questions regarding the use of autografts. Which of the following statements is true regarding bone-patellar tendon-bone (BTB) autograft in comparison to quadrupled hamstring autograft for ACL reconstruction?

16 / 50

Pharmacologically induced apoptosis occurs during the medical therapy of which of the following disorders?

17 / 50

Which of the following correctly lists the life expectancy from least life expectancy to greatest life expectancy when a patient presents with metastatic carcinoma to bone?

18 / 50

Tyrosine kinase inhibitors are currently used in the medical treatment of which of the following?

19 / 50

Which of the following most accurately lists the most common location of osteosarcoma in decreasing frequency?

20 / 50

A 63-year-old female sustains a subtrochanteric femoral fracture after a fall in her home. Five years ago she underwent resection of a left thigh leiomyosarcoma with adjuvant radiotherapy. All the following are known risk factors for development of pathologic fracture post radiotherapy EXCEPT:

21 / 50

Estrogen receptor blockade has been moderately successful treating which of the following tumors, while reducing the morbidity of side-effects associated with previous treatments?

22 / 50

Endothelin 1 is known to be involved in which of the following disease processes?

23 / 50

A 13-year-old boy is diagnosed with osteosarcoma of his distal femur. The treating surgeon samples the bone marrow from the resection margin of the femur during definitive limb salvage surgery and finds microscopic evidence of tumor. Assuming no change in the resection level, what type of resection would this be considered?

24 / 50

Intralesional curettage and bone grafting is an accepted component of the treatment plan for all of the following conditions EXCEPT?

25 / 50

What is the most common cause for an aggressive lytic bone lesion in a patient above 40-years-old?

26 / 50

A 24-year-old man has had pain in the right index finger for the past 9 months. The pain is completely relieved with ibuprofen. An AP radiograph and CT scan are shown in Figures A and B respectively. Which of the following is true regarding this lesion?

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27 / 50

A 59-year-old female presents with a metastatic spinal tumor and has a lytic lesion in the T12 vertebral body. The process of bone resorption in her lytic lesion is mediated by :

28 / 50

What is the most common malignant solid tumor of childhood?

29 / 50

Tightness in which of the following muscles has been implicated as an etiology for congenital muscular torticollis?

30 / 50

Which of the following is true regarding apoptosis?

31 / 50

Heterotopic ossification has been recognized as a rare complication from Steinmann pins placed in which location for traction purposes?

32 / 50

Sixty Gy is a typical radiation dose for which of the following indications?

33 / 50

All of the following statements regarding Paget’s sarcoma are correct EXCEPT?

34 / 50

A 65-year-old patient without a history of cancer presents with thigh pain and a lytic lesion in the left femur. A CT scan of the chest, abdomen, and pelvis as well as a bone scan show this to be an isolated tumor. Biopsy confirms adenocarcinoma. What is the most likely primary source of this patient’s tumor?

35 / 50

The fusion gene resulting from the chromosomal translocation t(X;18)(p11;q11) is chararcteristically found in which malignancy?

36 / 50

What is the most appropriate treatment for a 65-year-old female with a 100-pack year tobacco history who presents with a new painful lytic lesion in her femoral diaphysis?

37 / 50

All of the following have been shown in the literature to increase the risk of heterotopic ossification EXCEPT?

38 / 50

Which of the following tumors is chemotherapy and radiation therapy resistant?

39 / 50

A 59-year-old female with a history of biopsy proven metastatic renal cell carcinoma presents with a thoracic spine lesion consistent with renal cell carcinoma. She has lower extremity weakness and sustained clonus bilaterally. What is the most appropriate management prior to surgery?

40 / 50

A 8-year-old boy presents with knee pain and an effusion. Biopsy and staging studies show a distal femoral osteosarcoma with contamination of the knee joint. Which of the following treatment options will provide this child with the best chance of local control and the highest level of function?

41 / 50

A 9-year-old child presents to your office after he felt a painful snap in his arm while throwing a baseball. He is otherwise in good health and has no family history of disease. A radiograph of his arm is shown in Figure . What is the next step in your management?

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42 / 50

A 58-year-old man presents to your clinic with a 4-cm deep mass in his left thigh. It has been slowly expanding over the last 6 months. Radiographs show no evidence of bony involvement or soft tissue calcifications within the lesion. Which of the following is most appropriate at this time?

43 / 50

Intralesional surgical resection is considered standard of care for which of the following conditions?

44 / 50

A 22-year-old female with hereditary osteochondromas has difficulty supinating and pronating her forearm. Radiographs are shown in Figure A. Which of the following procedures would most effectively improve forearm rotation in this patient?

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45 / 50

A 14-year-old boy is brought to the emergency department after falling onto his right shoulder. Radiographs are shown in Figure A. Which of the following is most likely to occur with curettage and bone grafting of this lesion?

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46 / 50

Patients with which of the following conditions have the highest risk of malignant transformation?

47 / 50

Which of the following statements regarding rhabdomyosarcoma is true?

48 / 50

Each of the following neoplasms demonstrate round cells when examined histologically EXCEPT

49 / 50

A 53-year old female presents to your community hospital with right shoulder pain of 2 weeks duration, night sweats, and loss of appetite. Her past medical history is significant for hypertension only. A radiograph is performed and is shown in Figure A. What is the most appropriate next step in management؟

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50 / 50

Metastatic bony lesions that occur distal to the elbows or knees are most likely to originate from which one of the following primary organs?

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